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Desaturases convert omega-3 PUFA ALA into EPA and the latter into DHA

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CD8+ T cells and neutrophils promote cancer cell ferroptosis by secreting interferon (IFN-) and transferring myeloperoxidase-containing particles, followed by the release of immunostimulatory signals from ferroptotic cancer cells, which promotes the maturation of dendritic cells (DCs), the activation of M1-polarized macrophages, and the enhancement of intratumoral T-cell infiltration and activity (10)

However, some animal studies have shown promising results in rats

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